Major Research Interests
Our lab is interested in understanding epigenetic regulation of transcription in the mammalian genome that governs development and related human diseases. For this purpose we use a variety of methods in molecular biology, developmental biology, genomics and bioinformatics. By combining “wet” lab and “dry” lab, we aim to decipher the mechanisms underlying a number of key biological processes including the following areas:

(1) Epigenetic regulation of early animal development mediated by DNA methylation and chromatin modifications.
(2) Epigenetic regulation of pluripotency and stem cell differentiation.
(3) The role of cis-regulatory elements such as enhancers, promoters, insulators and 3D chromatin structure in development and cell fate determination.
(4) Molecular mechanisms underlying human diseases linked to aberrant epigenetic regulation.